KL2 Training Grant
The CTSI KL2 Multidisciplinary Scholars Program is a research training and funding opportunity for junior faculty at UF to foster a career in clinical/ translational research. Didactic coursework, mentored research and multidisciplinary teamwork are offered to develop the skills necessary to build a well-funded collaborative research career.
KL2 Scholars receive salary support each year for two years to cover approximately 75 percent assigned effort of the current total base salary up to a maximum of a total base salary of $181,500 (representing the NIH salary cap) plus fringe benefits. Support may be extended beyond two years in only rare, selected circumstances. Up to $9,500 per year will be available for a scholar’s research activities, textbooks and course supplies. In addition, the program provides $2,500 per year to support mentors’ research, $3,750 for CTSI biostatistical support ($75/hour x 50 hours), $2,617 tuition and fees for a scholar to enroll in courses of interest related to his/her research, and $2,500 per year for a scholar to travel to one academic conference. Scholars receive advice and oversight from the KL2 Multidisciplinary Advisory Committee (MAC). KL2 funding will terminate if subsequent extramural funding with salary support is awarded prior to the completion of two years in the KL2 program.
Applicants to the KL2 program must:
- Be a U.S. citizen or legal permanent resident, as this is required by the KL2 support mechanism
- Have a clinical doctorate (M.D., DMD, DVM, PharmD, etc.) or Ph.D. degree or its equivalent in health sciences
- Have department and division guarantee of 75 percent of full-time professional effort dedicated for program participation and for related clinical research activities. May be negotiable to a minimum of 50 percent effort/ salary support for selected situations, such as clinicians with substantial clinical technical roles who require maintenance of clinical and technical proficiency.
- Propose a research project that is clinical/ translational and multidisciplinary in nature, is relevant to human health and will lead to results suitable to serve as the foundation for a successful research grant application
- Hold a current UF faculty position as an assistant professor, preferably within one to three years of first appointment
- Identify established, funded mentors who have the interest and time to provide guidance and research expertise for the planned project
- Possess strong academic credentials and good communication skills
- Have a strong interest in developing a career in multidisciplinary clinical or translational research
- Not be or have been a principal investigator on an NIH-funded R01, R29 or a subproject of a Program Project (P01) grant, Center (P50, P60, U54) grant, mentored career development (K-series) grant, or other equivalent research grant award (including national career development awards that provide both annual salary support and research funds, such as the AHA Scientist Development Grant). Note: R03 and R21 awardees are eligible to apply.
- Have the ability to commit to full participation in all requirements of the training program, including the intensive Summer B course, GMS 7093, Introduction to Clinical & Translational Research, held in the summer for 11 consecutive days, typically in mid-July
- Adhere to the directives outlined in the mentoring plan and progress reports
- Complete semi-annual progress reports
- Participate in the annual UF CTSI Research Day
- Present their research at the national CTSA Translational Research meeting each spring
KL2 Scholars are expected to conduct an independent research project that is clinical or translational in nature and designed to be completed well within the two years of program participation. The project must be clearly clinical/ translational in nature (see Definitions below). This project is expected to result in sufficient pilot findings that will permit the submission of a multidisciplinary R01 grant (or equivalent) by the second year of program participation. The project needs to take advantage of CTSI resources and cores.
Each applicant must choose a lead mentor and one or more co-mentor(s). At least one mentor from each of two different disciplines will be required. The mentors will facilitate and promote their scholar’s research and interactions with other CTSI trainees. They will also ensure that the KL2 Scholar has the appropriate amount of guaranteed dedicated time and has access to adequate resources to conduct his/ her CTS project. If the applicant is accepted, a member of the KL2 Multidisciplinary Advisory Committee (MAC) will be assigned to the scholar’s mentor team.
The primary mentor is required to have a solid track record of extramural funding. The primary mentor and any additional mentors should have expertise in the area(s) of proposed KL2 research.
Each KL2 Scholar must develop a mentoring plan outlining specific benchmarks, including timelines for completion of the research project, meeting presentations, publications and grant applications, and planned didactic courses or degree programs. The mentoring plan will be discussed and approved by the mentoring team with the MAC providing final approval. The KL2 Scholar must also complete a semiannual progress report describing the specific activities and accomplishments and whether the benchmarks have been reached. KL2 Scholars will also be contacted annually for a minimum of 10 years after completing the program to assess career progress.
KL2 Scholar awards pay 75% of each scholar’s salary; therefore, the scholar’s department must agree to the following:
- Scholar will spend 75% of his/ her FTE on KL2 didactics, research and other KL2 Scholar activities
- This 75% of FTE is based on the scholar’s workweek schedule at time of entry into the program
- The scholar will relocate his/ her primary office space to the Clinical and Translational Research Building during the two years of KL2 participation
- Any changes to the scholar’s schedule that could infringe upon this 75% time must be discussed with the KL2 directorship
Selection Process & Criteria
Scholars are selected for support based on a competitive review process in which academic qualifications, career goals, and the quality of the training environment will be important considerations for funding. Finalists are interviewed by members of the KL2 MAC.
Criteria for Selection
- Track Record: Creativity of the candidate and potential to lead excellent multidisciplinary research judging by track record in some or all of the following: areas of expertise and prior training; number of first- or senior-author publications; funded grants; written product attached to the application
- Research Plan: Scientific value, potential clinical importance, and feasibility of the written multidisciplinary research plan. Likelihood of the research project to result in a larger independently funded peer-reviewed grant. Utilization of CTSI cores and resources.
- Mentors: Quality, appropriateness, track record of previous trainees, record of research funding (NIH or equivalent funding is preferred) and multidisciplinary expertise of the proposed mentor(s)
- Resources: Tangible commitment and resources provided by the home department, and suitability of the available clinical and laboratory infrastructure and multidisciplinary team
- Career Potential: Global assessment of the likelihood that the candidate will develop a career as an outstanding investigator who will lead multidisciplinary teams and have an important impact on health
- Departmental Support: Clear commitment from the candidate’s department to respect the candidate’s effort in the program and value the candidate’s career as a clinical/ translational researcher
- Clinical Research: Patient-oriented research, including epidemiologic and behavioral studies, outcomes research, and health services research. Patient-oriented research is research conducted with human subjects (or on material of human origin such as tissues, specimens, and cognitive phenomena) in which a researcher directly interacts with human subjects. It includes research on mechanisms of human disease, therapeutic interventions, clinical trials, and development of new technologies, but does not include in vitro studies using human tissues not linked to a living individual. Studies falling under 45 CFR 46.101(b) (4) are not considered clinical research for purposes of this definition. (Source: http://grants.nih.gov/grants/glossary.htm)
- Translational Research: Translational research includes two areas of translation. One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans. The second area of translation concerns research aimed at enhancing the adoption of best practices in the community. Cost-effectiveness of prevention and treatment strategies is also an important part of translational science. (Source: http://grants.nih.gov/grants/glossary.htm)
- Permanent Resident: Someone who has been granted authorization to live and work in the United States on a permanent basis. As proof of that status, a person is granted a permanent resident card, commonly called a “green card.” (Source: U.S. Citizen and Immigration Services)