2018 – 2019 TDDC Publications

See below for a list of publications that highlight research that was conducted with the support of the CTSI’s Translational Drug Development Core.


Kamble SH, Sharma A, King TI, León F, McCurdy CR, Avery BA. Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica. 2019 Nov;49(11):1279-1288. doi: 10.1080/00498254.2018.1552819. Epub 2019 Jan 7. PMID: 30547698.

King TI, Sharma A, Kamble SH, León F, Berthold EC, Popa R, Cerlati O, Prentice BM, McMahon LR, McCurdy CR, Avery BA. Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies. J Pharm Biomed Anal. 2020 Feb 20;180:113019. doi: 10.1016/j.jpba.2019.113019. Epub 2019 Dec 5. PMID: 31838282; PMCID: PMC7350276.

King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Dec 15;1134-1135:121875. doi: 10.1016/j.jchromb.2019.121875. Epub 2019 Nov 12. PMID: 31790916; PMCID: PMC7027589.

Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, León F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. J Med Chem. 2020 Jan 9;63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. Epub 2019 Dec 27. PMID: 31834797; PMCID: PMC7676998.

Prozialeck WC, Avery BA, Boyer EW, Grundmann O, Henningfield JE, Kruegel AC, McMahon LR, McCurdy CR, Swogger MT, Veltri CA, Singh D. Kratom policy: The challenge of balancing therapeutic potential with public safety. Int J Drug Policy. 2019 Aug;70:70-77. doi: 10.1016/j.drugpo.2019.05.003. Epub 2019 May 16. PMID: 31103778; PMCID: PMC7881941.

Sharma A, Kamble SH, León F, Chear NJ, King TI, Berthold EC, Ramanathan S, McCurdy CR, Avery BA. Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2019 Aug;11(8):1162-1171. doi: 10.1002/dta.2604. Epub 2019 May 15. PMID: 30997725; PMCID: PMC7927418.


Avery BA, Boddu SP, Sharma A, Furr EB, Leon F, Cutler SJ, McCurdy CR. Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats. Planta Med. 2019 Mar;85(4):340-346. doi: 10.1055/a-0770-3683. Epub 2018 Nov 16. PMID: 30452072.